KINETICS AND MECHANISM FOR OXIME FORMATION FROM PYRIDINE-2-CARBOXALDEHYDE, PYRIDINE-3-CARBOXALDEHYDE, AND PYRIDINE-4-CARBOXALDEHYDE

被引：10
|
作者：
MALPICA, A
CALZADILLA, M
BAUMRUCKER, J
JIMENEZ, J
LOPEZ, L
ESCOBAR, G
MONTES, C
机构：
[1] Escuela de Química, Facultad de Ciencias, Universidad Central Caracas
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 12期
关键词：
D O I：
10.1021/jo00091a031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Grime formation from pyridine-2-, -3-, and -4-carboxaldehydes occurs with rate-limiting carbinolamine dehydration under both acidic and neutral conditions. Carbinolamine dehydration of pyridine-2-carboxaldehyde occurs via a transition state bearing a single positive charge, unlike the corresponding reaction for formyl-1-methylpyridinium ion and the reaction under acidic conditions for pyridine-3- and -4-carboxaldehydes.
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页码：3398 / 3401
页数：4
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