SOLUBLE COMBINATORIAL LIBRARIES OF ORGANIC, PEPTIDOMIMETIC AND PEPTIDE DIVERSITIES

被引：35

作者：

BLONDELLE, SE ^{[1
]}

PEREZPAYA, E ^{[1
]}

DOOLEY, CT ^{[1
]}

PINILLA, C ^{[1
]}

HOUGHTEN, RA ^{[1
]}

机构：

[1] TORREY PINES INST MOLEC STUDIES,SAN DIEGO,CA

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 1995年 / 14卷 / 02期

关键词：

D O I：

10.1016/0165-9936(95)91476-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Molecular diversity provides a source of novel lead compounds for drug discovery. In particular, soluble combinatorial libraries composed of millions of peptides, peptidomimetics and organic compounds have lead to the successful identification of new pharmacophores. The current development of structurally defined combinatorial libraries will broaden the applicability of combinatorial chemistry.

引用

页码：83 / 92

页数：10

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