REDUNDANT MECHANISMS OF CALCIUM-INDUCED CALCIUM-RELEASE UNDERLYING CALCIUM WAVES DURING FERTILIZATION OF SEA-URCHIN EGGS

被引：289
|
作者：
GALIONE, A
MCDOUGALL, A
BUSA, WB
WILLMOTT, N
GILLOT, I
WHITAKER, M
机构：
[1] JOHNS HOPKINS UNIV,DEPT BIOL,BALTIMORE,MD 21218
[2] UNIV LONDON UNIV COLL,DEPT PHYSIOL,LONDON WC1E 6BT,ENGLAND
来源：
SCIENCE | 1993年 / 261卷 / 5119期
基金：
英国惠康基金;
关键词：
D O I：
10.1126/science.8392748
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Propagating Ca2+ waves are a characteristic feature of Ca2+-linked signal transduction pathways. Intracellular Ca2+ waves are formed by regenerative stimulation of Ca2+ release from intracellular stores by Ca2+ itself. Mechanisms that rely on either inositol trisphosphate or ryanodine receptor channels have been proposed to account for Ca2+ waves in various cell types. Both channel types contributed to the Ca2+ wave during fertilization of sea urchin eggs. Alternative mechanisms of Ca2+ release imply redundancy but may also allow for modulation and diversity in the generation of Ca2+ waves.
引用
收藏
页码：348 / 352
页数：5
相关论文
共 50 条
12345