THE SYNTHESIS OF PYRANOACRIDINONE INHIBITORS OF PROTEIN-TYROSINE KINASES

被引：23

作者：

GROUNDWATER, PW

SOLOMONS, KRH

机构：

[1] School of Chemistry and Applied Chemistry, University of Wales, College of Cardiff, Cardiff CF1 3TB

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 02期

关键词：

D O I：

10.1039/p19940000173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7-Oxo-5,6,7,8-tetrahydroflavone 10 reacts with anthranilonitrile and ethyl anthranilate to give the corresponding enamines. 11 and 13. These enamines undergo base-catalysed cyclization to pyrano[2,3-a] acridin-4-ones, 12 and 14. which undergo oxidation to the fully aromatic systems. 4 and 5. Biological testing of some of these fused heterocyclic systems shows them to have potential in cancer chemotherapy as inhibitors of growth factor-mediated cell proliferation.

引用

页码：173 / 177

页数：5

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