TPA-INDUCED ACTIVATION OF MAP KINASE

被引：69

作者：

ADAMS, PD ^{[1
]}

PARKER, PJ ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,PROT PHOSPHORYLAT LAB,44 LINCOLNS INN FIELDS,LONDON WC2A 3PX,ENGLAND

来源：

FEBS LETTERS | 1991年 / 290卷 / 1-2期

关键词：

MAP KINASE; PROTEIN KINASE-C; PHORBOL ESTER;

D O I：

10.1016/0014-5793(91)81230-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Threonine and tyrosine residue phosphorylation of a 42 kDa protein identified as mitogen-activated protein kinase (MAP kinase) was stimulated in extracts from TPA-pretreated cells. It is further shown that TPA pretreatment leads to the enhancement of an activity that will induce reactivation of dephosphorylated/inactivated MAP kinase. This TPA-induced activity induces the threonine and tyrosine phosphorylation of p42 in extracts from unstimulated cells.

引用

页码：77 / 82

页数：6

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