SYNTHESIS OF [2-C-14] FANTOFARONE OR 1-[4-[3-N-METHYL N-[3,4-DIMETHYL BETA-PHENETHYL] AMINO PROPYLOXY] BENZENE SULFONYL] 2-ISOPROPYL [2-C-14] INDOLIZINE

被引：1

作者：

POINTEAU, P ^{[1
]}

BERGER, Y ^{[1
]}

机构：

[1] SANOFI RECH,F-34184 MONTPELLIER 04,FRANCE

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 11期

关键词：

INDOLIZINE; C-14; CALCIUM ANTAGONIST;

D O I：

10.1002/jlcr.2580341104

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Sodium [1-C-14] isobutyrate : 1 was obtained by carbonation of isopropyl magnesium bromide with (CO2)-C-14. From : 1 [1-C-14] isobutyryl chloride : a was prepared, which through the successive actions of diazomethane and hydrogen bromide gave rise to 1-bromo 3 methyl [2-C-14] 2-butanone: 5. The latter lead to the indolizine : 6 which by a route patterned after that used to make unlabelled Fantofarone gave the [2-C-14-indolizyl] Fantofarone : 8 (specific radioactivity : 58.2 mCi/mMole) overall yield 9.9% based on [C-14] BaCO3.

引用

页码：1023 / 1029

页数：7

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