CLONING AND SEQUENCING OF THE CDNA-ENCODING A HUMAN TESTIS PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE

被引：85
|
作者：
ESWORTHY, RS
DOAN, K
DOROSHOW, JH
CHU, FF
机构：
[1] Department of Medical Oncology, Therapeutics Research, City of Hope National Medical Center, Duarte
来源：
GENE | 1994年 / 144卷 / 02期
关键词：
SELENIUM-DEPENDENT GLUTATHIONE PEROXIDASE; HOMOLOGY; PHOSPHORYLATION; OPAL CODON SUPPRESSION;
D O I：
10.1016/0378-1119(94)90400-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A human cDNA that encodes a polypeptide that has 94% deduced amino-acid sequence identity to porcine phospholipid hydroperoxide glutathione peroxidase was cloned from a testis library. The sequence shows preservation of the UGA selenocysteine codon, putative active-site Trp and Glu residues and a Tyr residue that is phosphorylated in the porcine protein. The 3'-UTR shows some conservation of sequences implicated in the insertion of selenocysteine at an opal codon in human glutathione peroxidase-1.
引用
收藏
页码：317 / 318
页数：2
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