EXTREME VARIATIONS IN THE RATIOS OF NON-SYNONYMOUS TO SYNONYMOUS NUCLEOTIDE SUBSTITUTION RATES IN SIGNAL PEPTIDE EVOLUTION

被引：6

作者：

GARCIAMAROTO, F ^{[1
]}

CASTAGNARO, A ^{[1
]}

DELAHOZ, PS ^{[1
]}

MARANA, C ^{[1
]}

CARBONERO, P ^{[1
]}

GARCIAOLMEDO, F ^{[1
]}

机构：

[1] UNIV POLITECH MADRID, ESCUELA TECN SUPER INGN TELECOM, CATEDRA BIOQUIM & BIOL MOLEC, E-28040 MADRID, SPAIN

来源：

FEBS LETTERS | 1991年 / 287卷 / 1-2期

关键词：

ALPHA-AMYLASE TRYPSIN INHIBITOR; THAUMATIN-II; THIONIN; PLASTOCYANIN; SIGNAL PEPTIDE EVOLUTION;

D O I：

10.1016/0014-5793(91)80017-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleotide sequences encoding signal peptides from the precursors of alpha-amylase/trypsin inhibitors from cereals are homologous to those corresponding to the precursors of thaumatin II and of plastocyanins. Non-synonymous (K(A)) and synonymous (K(S)) rates of nucleotide substitutions have been calculated for all possible binary combinations. Extreme variation in K(A)/K(S) ratios has been observed; from the 0.167 average found within the plastocyanin family to an average of 1.90 calculated for the inhibitors/thaumatin II transition. A similar calculation has been carried out for the signal peptide sequences of thionins, which are unrelated to those of the alpha-amylase/trypsin inhibitor family, and an average K(A)/K(S) of 0.12 has been obtained. This variation can be largely explained in terms of an empirical index of stability related to amino acid composition and seems to be independent of functional constraints.

引用

页码：67 / 70

页数：4

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