HETEROZYGOSITY AND HOMOZYGOSITY OF MHC CLASS-II GENE-PRODUCTS IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：13

作者：

HARTUNG, K

COLDEWEY, R

KRAPF, F

LANG, B

SPECKER, C

SCHENDEL, D

SCHNEIDER, P

SEUCHTER, S

STANGEL, W

ALBERT, E

DEICHER, H

机构：

[1] UNIV HANOVER,W-3000 HANNOVER,GERMANY

[2] UNIV FREIBURG,W-7800 FREIBURG,GERMANY

[3] UNIV ERLANGEN NURNBERG,W-8520 ERLANGEN,GERMANY

[4] UNIV DUSSELDORF,W-4000 DUSSELDORF 1,GERMANY

[5] UNIV BIELEFELD,W-4800 BIELEFELD,GERMANY

[6] UNIV BONN,W-5300 BONN,GERMANY

[7] UNIV MAINZ,W-6500 MAINZ,GERMANY

[8] UNIV MUNICH,W-8000 MUNICH 2,GERMANY

[9] UNIV BERN,CH-3000 BERN,SWITZERLAND

[10] UNIV ANCONA,I-60100 ANCONA,ITALY

[11] UNIV AMSTERDAM,CENT LAB NETHERLANDS RED CROSS BLOOD TRANSFUS SERV,AMSTERDAM,NETHERLANDS

[12] UNIV AMSTERDAM,EXPTL & CLIN IMMUNOL LAB,AMSTERDAM,NETHERLANDS

来源：

TISSUE ANTIGENS | 1991年 / 38卷 / 04期

关键词：

SYSTEMIC LUPUS-ERYTHEMATOSUS; GENETICS; HLA ANTIGENS; HETEROZYGOSITY; MHC;

D O I：

10.1111/j.1399-0039.1991.tb01890.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An analysis of HLA class II antigens in 356 white patients with systemic lupus erythematosus (SLE) showed that all HLA-DR and -DQ homozygous and heterozygous combinations appear with frequencies expected from the observed gene frequencies. HLA-DR2 and HLA-DR3 gene frequencies were both increased in SLE, as were the odds ratios of all DR2 and DR3 hetero- and homozygous combinations. HLA-DR2/C4AQ0 heterozygotes were also not increased over expected values. Therefore, gene complementation at MHC loci does not contribute to susceptibility to SLE, but rather one or two MHC allele(s) in linkage with HLA-DR2 and HLA-DR3.

引用

页码：165 / 168

页数：4

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