THE 38-KDA PROTEIN OF MYCOBACTERIUM-TUBERCULOSIS - A REVIEW

被引：101
|
作者：
HARBOE, M
WIKER, HG
机构：
[1] Institute of Immunology and Rheumatology, University of Oslo
来源：
JOURNAL OF INFECTIOUS DISEASES | 1992年 / 166卷 / 04期
关键词：
D O I：
10.1093/infdis/166.4.874
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review illustrates that the 38-kDa protein is one of the most important antigens of Mycobacterium tuberculosis. It is actively secreted but partly attached to the surface of the mycobacterial cell by a lipid tail that may also be responsible for binding of carbohydrate to the protein. It is a major constituent of M. tuberculosis culture fluid after growth on the synthetic Sauton medium and occurs in bacille Calmette-Guerin in far lower concentrations. The protein induces B and T cell responses with high specificity for infection with M. tuberculosis and is a prime candidate for development of new diagnostic reagents for tuberculosis.
引用
收藏
页码：874 / 884
页数：11
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