EFFECTS OF SINGLE DOSES OF ALPRAZOLAM AND DIAZEPAM, ALONE AND IN COMBINATION WITH ETHANOL, ON PSYCHOMOTOR AND COGNITIVE PERFORMANCE AND ON AUTONOMIC NERVOUS-SYSTEM REACTIVITY IN HEALTHY-VOLUNTEERS

被引：58
|
作者：
LINNOILA, M
STAPLETON, JM
LISTER, R
MOSS, H
LANE, E
GRANGER, A
ECKARDT, MJ
机构：
[1] Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 01期
关键词：
Benzodiazepines; Cognition; Drug interaction; Ethanol; Psychomotor;
D O I：
10.1007/BF02657051
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of alprazolam, alone and in combination with ethanol, on psychomotor and cognitive performance were studied in healthy male volunteers and compared to effects of diazepam. Alprazolam 2 mg produced relatively long-lasting impairments on tests of tracking, verbal and nonverbal information processing, and memory, and decreased blood pressure without a change in heart rate or plasma norepinephrine levels. Although ethanol consumption was demonstrated to produce additive decrements in performance on certain tasks, there was little evidence to support a synergistic effect. Alprazolam 2 mg was accompanied by increased selfreports of side effects, especially drowsiness. Low dose alprazolam, diazepam, and ethanol produced significantly fewer side effects than 2 mg alprazolam, but significantly more than placebo. © 1990 Springer-Verlag.
引用
收藏
页码：21 / 28
页数：8
相关论文
共 33 条
  • [21] INTERACTION IN RATS OF SINGLE DOSES OF PHENYTOIN AND ETHANOL IN THE SCOPE OF THEIR EFFECTS ON THE CENTRAL NERVOUS-SYSTEM
    KIELEK, MB
    SZADOWSKA, A
    ACTA POLONIAE PHARMACEUTICA, 1981, 38 (01): : 129 - 134
  • [22] The effects of subanesthetic concentrations of sevoflurane and nitrous oxide, alone and in combination, on analgesia, mood, and psychomotor performance in healthy volunteers
    Janiszewski, DJ
    Galinkin, JL
    Klock, PA
    Coalson, DW
    Pardo, H
    Zacny, JP
    ANESTHESIA AND ANALGESIA, 1999, 88 (05): : 1149 - 1154
  • [23] Effects of ceronapril alone or in combination with alcohol on psychomotor performance in healthy volunteers:: A placebo-controlled, crossover study
    Vanakoski, J
    Seppälä, T
    Strömberg, C
    Näveri, L
    Hammett, J
    Ford, N
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2001, 62 (10): : 699 - 708
  • [24] EFFECTS OF A SINGLE-DOSE OF 3 HYPNOTICS, AN ANTIDEPRESSANT AND A NEUROLEPTIC SEDATIVE ON PSYCHOMOTOR PERFORMANCE AND MEMORY IN HEALTHY-VOLUNTEERS
    WAROT, D
    BENSIMON, G
    DANJOU, P
    KREBS, MO
    PUECH, A
    THERAPIE, 1987, 42 (03): : 323 - 323
  • [25] EFFECTS OF EPLIVANSERIN, A DEEP SLEEP ENHANCER, ALONE AND IN COMBINATION WITH ZOLPIDEM, ON PSYCHOMOTOR AND COGNITIVE PERFORMANCE IN HEALTHY SUBJECTS
    Micallef-Roll, J.
    Roy, C.
    Delfolie, A.
    Pinquier, J.
    Blin, O.
    SLEEP, 2009, 32 : A36 - A36
  • [26] THE EFFECTS OF ACUTE DOSES OF METACLAZEPAM (KC 2547) ON CENTRAL NERVOUS-SYSTEM ACTIVITY, PSYCHOMOTOR PERFORMANCE AND MEMORY
    SUBHAN, Z
    HINDMARCH, I
    DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 1983, 9 (8-9) : 567 - 572
  • [27] Pharmacokinetics of Single Doses of Methadone and Buprenorphine in Blood and Oral Fluid in Healthy Volunteers and Correlation With Effects on Psychomotor and Cognitive Functions
    Strand, Maren Cecilie
    Ramaekers, Johannes G.
    Gjerde, Hallvard
    Morland, Jorg
    Vindenes, Vigdis
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2019, 39 (05) : 489 - 493
  • [28] Different acute tolerance development to EEG, psychomotor performance and subjective assessment effects after two intermittent oral doses of alprazolam in healthy volunteers
    Barbanoj, M. J.
    Urbano, G.
    Antonijoan, R.
    Ballester, M. R.
    Valle, M.
    NEUROPSYCHOBIOLOGY, 2007, 55 (3-4) : 203 - 212
  • [29] Biological and hemodynamic effects of single administrations of low doses of fludrocortisone and hydrocortisone, alone or in combination, in healthy volunteers with hypoaldosteronism
    Laviolle, B.
    Le Maguet, P.
    Massart, C.
    Verdier, M-C
    Donal, E.
    Lavenu, A.
    Laine, F.
    Bellissant, E.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2010, 24 : 30 - 30
  • [30] THE PHYSIOLOGICAL RELATIONSHIP BETWEEN CARDIAC CYCLE AND QT-DURATION IN HEALTHY-VOLUNTEERS - EFFECTS OF AUTOMATIC NERVOUS-SYSTEM MODIFICATIONS
    LECOCQ, B
    LECOCQ, V
    JAILLON, P
    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 1987, 10 (04): : 1028 - 1028
1234