Pathophysiology of CKD-MBD

被引：0
|
作者：
Elder, Grahame J. [1 ,2 ]
机构：
[1] Westmead Hosp, Dept Renal Med, Westmead, NSW 2145, Australia
[2] Garvan Inst Med Res, Osteoporosis & Bone Biol Program, Sydney, NSW, Australia
来源：
CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM | 2012年 / 10卷 / 03期
关键词：
CKD-MBD; Bone; Osteocyte; Osteoblast; Osteoclast; Fibroblast growth factor 23; Klotho; Parathyroid hormone; Renal adaptation; Pathophysiology;
D O I：
10.1007/s12018-011-9120-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To maintain calcium and phosphate balance despite declining kidney function, adaptations must begin in the earliest stages of chronic kidney disease (CKD). These are generally successful in maintaining calcium and phosphate levels within the normal range through CKD stages 1-4. Although routine biochemistry is not informative about net gain of these minerals, newer markers such as Klotho and fibroblast growth factor 23 may provide clues to these early adjustments and be of prognostic value. Bone cells play a central role in modulating responses to CKD. This review describes that role and highlights the dynamic communication between bone and the kidneys.
引用
收藏
页码：128 / 141
页数：14
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