The role of fatty acid desaturases in epidermal metabolism

被引：10
|
作者：
Sampath, Harini [1 ]
Ntambi, James M. [2 ,3 ]
机构：
[1] Oregon Hlth & Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97201 USA
[2] Univ Wisconsin Madison, Dept Biochem, Madison, WI 53706 USA
[3] Univ Wisconsin Madison, Dept Nutr Sci, Madison, WI 53706 USA
来源：
DERMATO-ENDOCRINOLOGY | 2011年 / 3卷 / 02期
关键词：
sebaceous lipids; skin barrier; sebocyte hypoplasia; skin lipids; energy balance;
D O I：
10.4161/derm.3.2.14832
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The lipid composition of skin is important to a variety of functions served by this organ. Therefore, skin expresses multiple enzymes that synthesize and metabolize lipids. An important class of lipid metabolism enzymes expressed in skin is the lipid desaturases. Various isoforms of stearoyl-CoA desaturase, a delta-9 desaturase, as well as a delta-6 desaturase alter the lipid composition of the skin, thereby affecting skin barrier homeostasis and consequently, whole body energy balance. This review will focus on the role of fatty acid desaturases in maintaining epidermal metabolism.
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页码：62 / 64
页数：3
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