SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW PYRIDAZINE DERIVATIVES

被引：6
|
作者：
ABDELGHANI, E
ASSY, MG
MOUSTAFA, HY
机构：
[1] Chemistry Department, Faculty of Science, Zagazig University, Zagazig
来源：
MONATSHEFTE FUR CHEMIE | 1995年 / 126卷 / 11期
关键词：
PYRIDAZINONE; PYRIDAZINETHIONE; CHLOROPYRIDIAZINE;
D O I：
10.1007/BF00824306
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Condensation of beta-aroyl-alpha-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl] propionic acid with hydrazine hydrate affords 4,5-dihydro-3(2H)-pyridazinone (2). Reaction of 2 with POCl3 and P2S5 gives a dichloro derivative (7) and a dithione (4). The behavior of the dichloro and dithione derivatives toward various reagents was studied. The in vitro antibacterial screening reveals moderate activities against certain bacteria.
引用
收藏
页码：1265 / 1270
页数：6
相关论文
共 50 条
  • [21] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW PYRIMIDINES
    ELBAHAIE, S
    ASSY, MG
    PHARMAZIE, 1989, 44 (07): : 489 - 490
  • [22] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW FLAVONES
    HOGALE, MB
    PAWAR, BN
    NIKAM, BP
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1987, 64 (08) : 486 - 487
  • [23] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW 8-HYDROXYQUINOLINE SULFONAMIDE DERIVATIVES
    ABDELHAFEZ, AA
    AWAD, IMA
    HASSAN, KM
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1988, 40 (3-4) : 219 - 225
  • [24] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME DERIVATIVES OF RIFAMYCIN-P
    CAVALLERI, B
    TURCONI, M
    TAMBORINI, G
    OCCELLI, E
    CIETTO, G
    PALLANZA, R
    SCOTTI, R
    BERTI, M
    ROMANO, G
    PARENTI, F
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) : 1470 - 1476
  • [25] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME AMIDE DERIVATIVES OF THE LANTIBIOTIC ACTAGARDINE
    MALABARBA, A
    PALLANZA, R
    BERTI, M
    CAVALLERI, B
    JOURNAL OF ANTIBIOTICS, 1990, 43 (09): : 1089 - 1097
  • [26] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME PHOSPHONIUM DERIVATIVES OF ITACONIC ACID
    VASSILEV, GN
    DOSEVA, VN
    TEREBENINA, AV
    DIMCHEVA, ZP
    BORISOV, G
    DOKLADI NA BOLGARSKATA AKADEMIYA NA NAUKITE, 1980, 33 (01): : 87 - 89
  • [27] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME HALOANILIDO PYRAZOLINE AND ISOXAZOLINE DERIVATIVES
    MANDAL, NK
    SINHA, R
    BANERJEE, KP
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1984, 61 (11-1) : 979 - 981
  • [28] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME PYRROLE DERIVATIVES .1.
    COCCO, MT
    CONGIU, C
    MACCIONI, A
    PLUMITALLO, A
    SCHIVO, ML
    PALMIERI, G
    FARMACO-EDIZIONE SCIENTIFICA, 1988, 43 (01): : 103 - 112
  • [29] SYNTHESIS OF SOME BENZOFURAN AND FUROCOUMARIN DERIVATIVES FOR POSSIBLE BIOLOGICAL-ACTIVITY
    HISHMAT, OH
    ELRAHMAN, AHA
    KHALIL, KMA
    MOAWAD, MI
    ATALLA, MM
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (09) : 1046 - 1049
  • [30] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME APORPHINE DERIVATIVES RELATED TO APOMORPHINE
    SAARI, WS
    KING, SW
    LOTTI, VJ
    SCRIABINE, A
    JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (10) : 1086 - 1090
12345