SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW PYRIDAZINE DERIVATIVES

被引：6

作者：

ABDELGHANI, E

ASSY, MG

MOUSTAFA, HY

机构：

[1] Chemistry Department, Faculty of Science, Zagazig University, Zagazig

来源：

MONATSHEFTE FUR CHEMIE | 1995年 / 126卷 / 11期

关键词：

PYRIDAZINONE; PYRIDAZINETHIONE; CHLOROPYRIDIAZINE;

D O I：

10.1007/BF00824306

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation of beta-aroyl-alpha-[1,3-diphenyl-5(4H)-oxo-pyrazol-4-yl] propionic acid with hydrazine hydrate affords 4,5-dihydro-3(2H)-pyridazinone (2). Reaction of 2 with POCl3 and P2S5 gives a dichloro derivative (7) and a dithione (4). The behavior of the dichloro and dithione derivatives toward various reagents was studied. The in vitro antibacterial screening reveals moderate activities against certain bacteria.

引用

页码：1265 / 1270

页数：6

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