EFFECT OF RECOMBINANT INTERLEUKIN-4 ON IMMUNOGLOBULIN-SYNTHESIS IN A CULTURE OF MONONUCLEAR-CELLS ISOLATED FROM HUMAN PERIPHERAL-BLOOD

被引：0
|
作者：
CHELIDZE, LK
LEBEDIN, YS
TSYTSIKOV, EN
PIVNYUK, VI
VASILOV, RG
机构：
[1] MINIST HLTH,INST BIOTECHNOL,MOLEC IMMUNOL LAB,MOSCOW,RUSSIA
[2] MINIST HLTH,INST PULM,MOSCOW,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 118卷 / 10期
关键词：
INTERLEUKIN-4; IGE; HAY FEVER;
D O I：
10.1007/BF02446476
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of recombinant interleukin-4 on the synthesis of immunoglobulins is studied in a culture of mononuclear cells isolated from peripheral blood of healthy donors and patients with hay fever. It is shown that interleukin-4 stimulates production of IgE in cells of healthy donors, but not of hay fever patients, and does not affect the synthesis of other isotypes in either group. At the same time, increased cell proliferation under the influence of interleukin-4 was observed in cultured cells of both healthy donors and patients.
引用
收藏
页码：1126 / 1128
页数：3
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