COMPARISON OF L-5-HYDROXYTRYPTOPHAN AND L-5-HYDROXYTRYPTOPHAN INOSINATE AS AGENTS FOR INCREASING BRAIN-SEROTONIN FORMATION IN RATS

被引：0
|
作者：
FULLER, RW
SNODDY, HD
ROBERTSON, DW
机构：
来源：
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY | 1992年 / 76卷 / 01期
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中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The effects of L-5-hydroxytryptophan (L-5HTP) and L-5HTP inosinate injection on brain 5-hydroxyindoles in rats were compared. L-5HTP and L-5HTP inosinate caused indistinguishable dose-dependent increases in 5HTP and 5HIAA (5-hydroxyindoleacetic acid) but not serotonin concentrations in whole brain at 1 hr in rats. Our results do not substantiate a previous claim that L-5HTP inosinate is superior to L-5HTP itself in increasing brain serotonin formation.
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页码：121 / 124
页数：4
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