COMPARISON OF L-5-HYDROXYTRYPTOPHAN AND L-5-HYDROXYTRYPTOPHAN INOSINATE AS AGENTS FOR INCREASING BRAIN-SEROTONIN FORMATION IN RATS

被引：0
|
作者：
FULLER, RW
SNODDY, HD
ROBERTSON, DW
机构：
来源：
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY | 1992年 / 76卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The effects of L-5-hydroxytryptophan (L-5HTP) and L-5HTP inosinate injection on brain 5-hydroxyindoles in rats were compared. L-5HTP and L-5HTP inosinate caused indistinguishable dose-dependent increases in 5HTP and 5HIAA (5-hydroxyindoleacetic acid) but not serotonin concentrations in whole brain at 1 hr in rats. Our results do not substantiate a previous claim that L-5HTP inosinate is superior to L-5HTP itself in increasing brain serotonin formation.
引用
收藏
页码：121 / 124
页数：4
相关论文
共 50 条
  • [1] L-5-HYDROXYTRYPTOPHAN AND MOOD
    TRIMBLE, M
    CHADWICK, D
    REYNOLDS, EH
    MARSDEN, CD
    [J]. LANCET, 1975, 1 (7906): : 583 - 583
  • [2] DISAGGREGATION OF BRAIN POLYSOMES BY L-5-HYDROXYTRYPTOPHAN - MEDIATION BY SEROTONIN
    WEISS, BF
    WURTMAN, RJ
    MUNRO, HN
    [J]. LIFE SCIENCES, 1973, 13 (05) : 411 - 416
  • [3] DIPSOGENIC EFFECT OF L-5-HYDROXYTRYPTOPHAN IN RATS
    FREGLY, MJ
    CONNOR, TM
    KIKTA, DC
    THREATTE, RM
    [J]. BRAIN RESEARCH BULLETIN, 1980, 5 (06) : 719 - 724
  • [4] MONOAMINE CHANGES IN BRAIN OF RATS INJECTED WITH L-5-HYDROXYTRYPTOPHAN
    OKADA, F
    SAITO, Y
    YAMASHITA, I
    FUJIEDA, T
    [J]. NATURE, 1972, 238 (5363) : 355 - +
  • [5] THERAPY OF MYOCLONUS WITH L-5-HYDROXYTRYPTOPHAN
    VANWOERT, MH
    SETHY, VH
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1975, 17 (02) : 246 - 246
  • [6] PERIPHERAL CONVERSION OF L-5-HYDROXYTRYPTOPHAN TO SEROTONIN INDUCED DRINKING IN RATS
    KIKTA, DC
    THREATTE, RM
    BARNEY, CC
    FREGLY, MJ
    GREENLEAF, JE
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1981, 14 (06) : 889 - 893
  • [7] AN ADVERSE REACTION TO L-5-HYDROXYTRYPTOPHAN
    BHUSHAN, B
    SETH, SD
    SAXENA, S
    GUPTA, YK
    KARMARKAR, MG
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1991, 148 (02): : 268 - 269
  • [8] ANTIHYPERTENSIVE EFFECTS OF FLUOXETINE AND L-5-HYDROXYTRYPTOPHAN IN RATS
    FULLER, RW
    HOLLAND, DR
    YEN, TT
    BEMIS, KG
    STAMM, NB
    [J]. LIFE SCIENCES, 1979, 25 (14) : 1237 - 1242
  • [9] L-5-HYDROXYTRYPTOPHAN (HTP) AS A DISCRIMINATIVE STIMULUS IN RATS
    WINTER, JC
    RABIN, RA
    [J]. FEDERATION PROCEEDINGS, 1987, 46 (03) : 548 - 548
  • [10] EFFECTS OF SEROTONIN AND L-5-HYDROXYTRYPTOPHAN ON PLASMA-RENIN ACTIVITY IN RATS
    BARNEY, CC
    THREATTE, RM
    KIKTA, DC
    FREGLY, MJ
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1981, 14 (06) : 895 - 900
12345