A RETROSPECTIVE EVALUATION OF ADVERSE REACTIONS TO TRIMETHOPRIM-SULFONAMIDE COMBINATIONS IN DOGS AND CATS

被引：43

作者：

NOLI, C ^{[1
]}

KOEMAN, JP ^{[1
]}

WILLEMSE, T ^{[1
]}

机构：

[1] UNIV UTRECHT,FAC VET MED,DEPT VET PATHOL,3508 TD UTRECHT,NETHERLANDS

来源：

VETERINARY QUARTERLY | 1995年 / 17卷 / 04期

关键词：

D O I：

10.1080/01652176.1995.9694550

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Adverse reactions to various trimethoprim-sulphonamide (T-S) combinations were studied retrospectively in dogs and cats referred to the Utrecht University Department of Clinical Sciences of Companion Animals during the period 1985-1994. Dermatological and systemic reactions were observed in 19 dogs and 2 cats. Specific histological reaction patterns were seen in 3 dogs with toxic epidermal necrolysis, in 1 dog and 1 cat with erythema multiforme, and in 1 dog with pemphigus foliaceus. Diagnostic criteria used in humans proved to be reliable in dogs and cats as well. Adverse reactions were observed within 7-14 days after administration and were most often due to sulphadiazine (76%) and sulphatroxazole (14%), The incidence of adverse reactions to T-S was 0.25%.

引用

页码：123 / 128

页数：6

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