STRUCTURE/FUNCTION STUDIES OF LIN-12 NOTCH PROTEINS

被引：108
|
作者：
GREENWALD, I
机构：
[1] Howadd Hughes Medical Institute, Department of Biochemical and Molecular Biophysics, Columbia University, New York, NY 10032
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 04期
关键词：
D O I：
10.1016/0959-437X(94)90072-B
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The lin-12/Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Recent structure/function studies have shown that the lin-12/Notch intracellular domain alone has the intrinsic signal-transducing activity of the intact protein, and that the role of the extracellular domain is to regulate this intrinsic activity. These studies have also suggested that the different lin-12/Notch proteins in a given organism are interchangeable biochemically and have addressed the role of lin-12/Notch genes in development.
引用
收藏
页码：556 / 562
页数：7
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