CHIRAL RESOLUTION OF 1,3-DIMETHYL-4-PHENYLPIPERIDINE DERIVATIVES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH A CHIRAL STATIONARY-PHASE

A number of racemic 1,3-dimethyl-4-phenylpiperidines which serve as intermediates in the synthesis of opioid analgesics have been resolved on two commercially available high-performance liquid chromatography columns containing cellulose-based chiral stationary phases: Chiralcel OD and Chiralcel OJ. The resolution results were complementary between the two columns. Also, the polarity of substituents appears to play an important role on the ability of the Chiralcel OD column to resolve pairs of enantiomers.