CHIRAL RESOLUTION OF 1,3-DIMETHYL-4-PHENYLPIPERIDINE DERIVATIVES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH A CHIRAL STATIONARY-PHASE

被引：9

作者：

YIN, D

KHANOLKAR, AD

MAKRIYANNIS, A

FROIMOWITZ, M

机构：

[1] UNIV CONNECTICUT,SCH PHARM,STORRS,CT 06268

[2] HARVARD UNIV,MCLEAN HOSP,SCH MED,BELMONT,MA 02178

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 678卷 / 01期

关键词：

D O I：

10.1016/0021-9673(94)87087-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of racemic 1,3-dimethyl-4-phenylpiperidines which serve as intermediates in the synthesis of opioid analgesics have been resolved on two commercially available high-performance liquid chromatography columns containing cellulose-based chiral stationary phases: Chiralcel OD and Chiralcel OJ. The resolution results were complementary between the two columns. Also, the polarity of substituents appears to play an important role on the ability of the Chiralcel OD column to resolve pairs of enantiomers.

引用

页码：176 / 179

页数：4

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