A POTENTIOMETRIC TITRATION STUDY OF THE INTERACTION OF HEPARIN WITH METAL-CATIONS

被引：21
|
作者：
GRANT, D
LONG, WF
WILLIAMSON, FB
机构：
[1] Department of Molecular Biology, University of Aberdeen, Marischal College
来源：
BIOCHEMICAL JOURNAL | 1992年 / 285卷
关键词：
D O I：
10.1042/bj2850477
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Potentiometric titrations, at ionic strengths (I) ranging from 0.0057 to 0.336, suggest that Ca2+, Cu2+, Li+ and Na+ bind to heparin in a manner that depends on cation identity. These interactions were less affected by the value of I than those of heparin with Mg2+, which binds weakly below I0.050 and with K+, which binds weakly at I0.0057. Of the interactions studied, that of heparin with Cu2+ was the least readily reversible.
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页码：477 / 480
页数：4
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