ANALGESIC PRINCIPLES FROM ARALIA-CORDATA THUNB

被引：0
|
作者：
OKUYAMA, E [1 ]
NISHIMURA, S [1 ]
YAMAZAKI, M [1 ]
机构：
[1] CHIBA UNIV, FAC PHARMACEUT SCI, 1-33 YAYOI CHO, CHIBA 260, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 02期
关键词：
ARALIA-CORDATA; KYOHKATSU; DOKUKATSU; QIANG-HUO; DU-HUO; (ENT)-KAUR-16-EN-19-OIC ACID; (ENT)-PIMARA-8(14); 15-DIEN-19-OIC ACID; PHARMACOLOGICALLY ACTIVE PRINCIPLE; ANALGESICS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The analgesic principles from Aralia cordata THUNB. were identified with (ent)-kaur-16-en-19-oic acid (KA) and (ent)-pimara-8(14),15-dien-19-oic acid (PA), respectively. Both compounds were significantly effective regarding analgesics, hypothermia, duration of pentobarbital-induced anesthesia, and depression of locomotor activity enhanced by methamphetamine at doses of 300 mg/kg (KA) and 500 mg/kg (PA) by oral administration.
引用
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页码：405 / 407
页数：3
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