A HUMAN HOMOLOG OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR MOM19 CAN ASSEMBLE WITH THE YEAST MITOCHONDRIAL RECEPTOR COMPLEX

被引：56
|
作者：
SEKI, N
MOCZKO, M
NAGASE, T
ZUFALL, N
EHMANN, B
DIETMEIER, K
SCHAFER, E
NOMURA, N
PFANNER, N
机构：
[1] UNIV FREIBURG, INST BIOL 2, D-79104 FREIBURG, GERMANY
[2] KAZUSA DNA RES INST, CHIBA 292, JAPAN
[3] UNIV FREIBURG, INST BIOCHEM, D-79104 FREIBURG, GERMANY
来源：
FEBS LETTERS | 1995年 / 375卷 / 03期
关键词：
MITOCHONDRION; HUMAN MOM19; PROTEIN SORTING; IMPORT RECEPTOR;
D O I：
10.1016/0014-5793(95)01229-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Import of preproteins into mitochondria requires transport machineries in both mitochondrial membranes that have been characterized in Saccharomyces cerevisiae and Neurospora crassa By cDNA analysis, we identified a human protein of 16 kDa with significant overall homology to the fungal mitochondrial import receptor Mom19, including the three typical characteristics: a hydrophobic N-terminal segment, a tetratrico peptide motif in the middle and a negatively charged C-terminus, The human Mom19 homolog is expressed in all tissues analyzed. When synthesized in vitro, the human Mom19 homolog is targeted to isolated yeast mitochondria and specifically associates with the outer membrane receptor complex, suggesting that indeed a mitochondrial import receptor was identified.
引用
收藏
页码：307 / 310
页数：4
相关论文
共 50 条
  • [41] Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the 'acid chain' hypothesis
    Komiya, T
    Rospert, S
    Koehler, C
    Looser, R
    Schatz, G
    Mihara, K
    EMBO JOURNAL, 1998, 17 (14): : 3886 - 3898
  • [42] The human mitochondrial import receptor, hTom20p, prevents a cryptic matrix targeting sequence from gaining access to the protein translocation machinery
    McBride, HM
    Goping, IS
    Shore, GC
    JOURNAL OF CELL BIOLOGY, 1996, 134 (02): : 307 - 313
  • [43] Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex
    Kang, Yilin
    Stroud, David A.
    Baker, Michael J.
    De Souza, David P.
    Frazier, Ann E.
    Liem, Michael
    Tull, Dedreia
    Mathivanan, Suresh
    McConville, Malcolm J.
    Thorburn, David R.
    Ryan, Michael T.
    Stojanovski, Diana
    MOLECULAR CELL, 2017, 67 (03) : 457 - +
  • [44] Sengers syndrome associated mitochondrial acylglycerol kinase, is a subunit of the human TIM22 protein import complex.
    Kang, Y.
    Stroud, D.
    Baker, M. J.
    De Souza, D. P.
    Frazier, A.
    Liem, M.
    Tull, D.
    Mathivanan, S.
    McConville, M.
    Thorburn, D.
    Ryan, M. T.
    Stojanovski, D.
    MOLECULAR BIOLOGY OF THE CELL, 2017, 28
  • [45] Protein sequences involved in the mitochondrial import of the 3,5,3′-L-triiodothyronine receptor p43
    Carazo, Angel
    Levin, Jonathan
    Casas, Francois
    Seyer, Pascal
    Grandemange, Stephanie
    Busson, Muriel
    Pessemesse, Laurence
    Wrutniak-Cabello, Chantal
    Cabello, Gerard
    JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 227 (12) : 3768 - 3777
  • [46] Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding
    Peleh, Valentina
    Cordat, Emmanuelle
    Herrmann, Johannes M.
    ELIFE, 2016, 5
  • [47] Transferrin Receptor 2 Protein Is Expressed in Mitochondrial-Associated Lysosomes During Human Erythropoiesis
    Noh, Seung-Jae
    Wu, Yun-Ping
    Byrnes, Colleen
    Lee, Y. Terry
    Miller, Jeffery L.
    BLOOD, 2009, 114 (22) : 260 - 260
  • [48] MITOCHONDRIAL IMPORT OF THE ADP/ATP CARRIER PROTEIN IN SACCHAROMYCES-CEREVISIAE - SEQUENCES REQUIRED FOR RECEPTOR-BINDING AND MEMBRANE TRANSLOCATION
    SMAGULA, C
    DOUGLAS, MG
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1988, 263 (14) : 6783 - 6790
  • [49] Re: Developmental Control of Apoptosis by the Immunophilin Aryl Hydrocarbon Receptor-Interacting Protein (AIP) Involves Mitochondrial Import of the Survivin Protein Editorial Comment
    Atala, Anthony
    JOURNAL OF UROLOGY, 2011, 186 (06): : 2495 - 2495
  • [50] Tracking the unfolding pathway of a multirepeat protein via tryptophan scanning -: Evidence of localized instability in the mitochondrial import receptor Tom70
    Bushell, Simon R.
    Bottomley, Stephen P.
    Rossjohn, Jamie
    Beddoe, Travis
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (34) : 24345 - 24350
12345