EFFECT OF ACETAZOLAMIDE ON REGIONAL CEREBRAL OXYGEN-SATURATION AND REGIONAL CEREBRAL BLOOD-FLOW

Background and Purpose To verify whether the monitoring of regional cerebral oxygen saturation (rSO(2)) with transcranial near-infrared spectroscopy would successfully reflect changes in intracranial hemodynamics but not changes in extracranial compartment, we measured rSO(2) and regional cerebral blood flow (rCBF) simultaneously in seven patients with cerebral ischemia and five normal volunteers before and after acetazolamide administration. Summary of Report The baseline values of rSO(2) and rCBF were 64.2+/-5.6% and 53.9+/-11.1 mL/100 g per minute, respec lively. rCBF increased by 44.4+/-23.3% and rSO(2) significantly increased to 69.6+/-5.6% after acetazolamide administration. Bilateral simultaneous measurement of rSO(2) indicated a tendency that the larger the Delta rSO(2), the greater the Delta%rCBF. The relationship between rSO(2) level and rCBF value fit significantly on the theoretical curve calculated from Fick's equation. Conclusions It is suggested that monitoring of rSO(2) with INVOS-3100 could be a useful indicator in the evaluation of intracranial hemodynamic changes.