THE DYNEMICIN DNA INTERCALATION COMPLEX - A MODEL BASED ON DNA AFFINITY CLEAVAGE AND MOLECULAR-DYNAMICS SIMULATION

被引：75

作者：

LANGLEY, DR ^{[1
]}

DOYLE, TW ^{[1
]}

BEVERIDGE, DL ^{[1
]}

机构：

[1] WESLEYAN UNIV,DEPT CHEM,HALL ATWATER LABS,MIDDLETOWN,CT 06457

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 12期

关键词：

D O I：

10.1021/ja00012a004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A model for the dynemicin-DNA complex has been constructed by using energy minimization (EM) and molecular dynamics (MD) techniques. The model is consistent with the available experimental data. This has allowed us to gain insights into (1) how dynemicin A is activated into a DNA cleaver, (2) its mode of binding to DNA, (3) the absolute stereochemistry of dynemicin A, and (4) its DNA cleavage patterns and specificity.

引用

页码：4395 / 4403

页数：9

共 50 条

[41] DNA-LIPID BILAYER INTERACTIONS MODELED BY MOLECULAR-DYNAMICS
FESSENDEN, JPM
GIORGIO, TD
FASEB JOURNAL, 1995, 9 (03): : A15 - A15
[42] TREFOIL KNOTTING REVEALED BY MOLECULAR-DYNAMICS SIMULATIONS OF SUPERCOILED DNA
SCHLICK, T
OLSON, WK
SCIENCE, 1992, 257 (5073) : 1110 - 1115
[43] MOLECULAR-DYNAMICS STUDIES OF SUPERCOILED DNA - GENERATION OF THERMODYNAMIC ENSEMBLES
TAN, RKZ
HARVEY, SC
BIOPHYSICAL JOURNAL, 1994, 66 (02) : A156 - A156
[44] MOLECULAR-DYNAMICS SIMULATIONS OF DNA WITH PRIMARY RADIATION-DAMAGE
OSMAN, R
MIASKIEWICZ, K
WEINSTEIN, H
FASEB JOURNAL, 1992, 6 (01): : A309 - A309
[45] MOLECULAR-DYNAMICS INVESTIGATIONS OF DNA BY DIELECTRIC-RELAXATION MEASUREMENTS
SORRISO, S
SUROWIEC, A
ADVANCES IN MOLECULAR RELAXATION AND INTERACTION PROCESSES, 1982, 22 (04): : 259 - 279
[46] MOLECULAR-DYNAMICS SIMULATION OF A PHOSPHOLIPASE-A2 SUBSTRATE COMPLEX
JONES, ST
AHLSTROM, P
BERENDSEN, HJC
PICKERSGILL, RW
BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1162 (1-2) : 135 - 142
[47] Ab initio molecular-dynamics simulation method for complex liquids
Shimojo, F
Hoshino, K
Zempo, Y
COMPUTER PHYSICS COMMUNICATIONS, 2001, 142 (1-3) : 364 - 367
[48] HIV-1 PROTEASE CLEAVAGE MECHANISM ELUCIDATED WITH MOLECULAR-DYNAMICS SIMULATION
CHATFIELD, DC
BROOKS, BR
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (20) : 5561 - 5572
[49] Molecular dynamics simulation of a DNA polymerase ternary complex containing a carcinogen-modified DNA template.
Yan, SX
Wu, M
Geacintov, NE
Broyde, S
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U762 - U762
[50] A Molecular Dynamics Study of DNA Bending in the IHF-DNA Complex
Wheatley, Elizabeth
Beveridge, David L.
Pieniazek, Susan
BIOPHYSICAL JOURNAL, 2010, 98 (03) : 470A - 470A

← 1 2 3 4 5 →