BIOLOGICAL RECEPTORS MEDIATE ANTIPROLIFERATIVE ACTION OF ATRIAL-NATRIURETIC-PEPTIDE IN CULTURED MESANGIAL CELLS

被引：29

作者：

HANEDA, M ^{[1
]}

KIKKAWA, R ^{[1
]}

KOYA, D ^{[1
]}

SAKAMOTO, K ^{[1
]}

NAKANISHI, S ^{[1
]}

MATSUDA, Y ^{[1
]}

SHIGETA, Y ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,TOKYO 194,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 192卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1463

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of anti-proliferative action of atrial natriuretic peptide (ANP) was examined in cultured mesangial cells. HS-142-1, a selective antagonist for ANP biological receptors, inhibited ANP-induced cellular cGMP accumulation and prevented ANP-induced inhibition of both serum-stimulated incorporation of 3H-thymidine and cell proliferation. Des-[Gln18, Ser19, Gly20, Leu21, Gly22]-ANP4-23-NH2 (C-ANP) failed to inhibit 3H- thymidine incorporation. These results indicate that anti-proliferative action of ANP is mediated by the biological receptors in cultured mesangial cells. © 1993 Academic Press, Inc.

引用

页码：642 / 648

页数：7

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