THE CGMP-GATED CHANNEL OF ROD OUTER SEGMENTS IS NOT LOCALIZED IN BIPOLAR CELLS OF THE MAMMALIAN RETINA

被引：33
|
作者：
WASSLE, H
GRUNERT, U
COOK, NJ
MOLDAY, RS
机构：
[1] MAX PLANCK INST BIOPHYS,FRANKFURT,GERMANY
[2] UNIV BRITISH COLUMBIA,DEPT BIOCHEM,VANCOUVER V6T 1W5,BC,CANADA
来源：
NEUROSCIENCE LETTERS | 1992年 / 134卷 / 02期
关键词：
ON-BIPOLAR CELL; CGMP-GATED CHANNEL; AMINO PHOSPHONOBUTYRIC ACID-RECEPTOR; PROTEIN KINASE C IMMUNOCYTOCHEMISTRY;
D O I：
10.1016/0304-3940(92)90516-A
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It has recently been suggested (Nature, 346 (1990) 269-271) that ON-bipolar cells express the same biochemical cascade and guanosine 3',5'-cyclic monophosphate (cGMP)-gated cation channel as rod outer segments. An antibody directed against the cGMP-gated channel of bovine rod outer segments was applied to cryostat sections of rat and cat retinae. No immunocytochemical labelling was found in bipolar cells. Therefore, if those cells express a cGMP-gated channel, it must be immunologically different to the 63 kDa protein constituting the cGMP-gated channel of the outer segment.
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页码：199 / 202
页数：4
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