CATHEPSIN-B IN SYNOVIAL-CELLS AT THE SITE OF JOINT DESTRUCTION IN RHEUMATOID-ARTHRITIS

被引：0
|
作者：
TRABANDT, A [1 ]
GAY, RE [1 ]
FASSBENDER, HG [1 ]
GAY, S [1 ]
机构：
[1] WHO,MAINZ,GERMANY
来源：
ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Based on the concept that proteolytic enzymes, like cathepsins, are associated with tissue destruction, we investigated the expression of the matrix-degrading cysteine proteinase cathepsin B in synovial tissues from the joints of patients with rheumatoid arthritis. The data indicate an enhanced transcription of cathepsin B in synovial cells when compared with normal fibroblasts, cathepsin B-producing epithelial tumor cells (SW1116), or fibroblasts derived from inflamed tonsils. Immunolocalization of cathepsin B appeared to be restricted mainly to the synovial cells attached to cartilage and bone at sites of rheumatoid joint erosion.
引用
收藏
页码：1444 / 1451
页数：8
相关论文
共 50 条
  • [31] PROCESSING OF INTERLEUKIN-1-BETA IN SYNOVIAL-CELLS FRESHLY ISOLATED FROM PATIENTS WITH RHEUMATOID-ARTHRITIS
    KOBAYASHI, Y
    ICHIJO, Y
    NAGATAKE, H
    WATANABE, N
    NISHIZAWA, K
    GOTO, M
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 199 (02) : 1035 - 1040
  • [32] The role of synovial fibroblasts in mediating joint destruction in rheumatoid arthritis
    Meinecke, I
    Rutkauskaite, E
    Gay, S
    Pap, T
    CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (05) : 563 - 568
  • [33] CATHEPSIN-B AND N-ACETYL-BETA-D-GLUCOSAMINIDASE IN HUMAN SYNOVIAL-CELLS IN CULTURE - EFFECTS OF INTERLEUKIN-1
    LECOMTE, V
    KNOTT, I
    BURTON, M
    REMACLE, J
    RAES, M
    CLINICA CHIMICA ACTA, 1994, 228 (02) : 143 - 159
  • [34] CARTILAGE DESTRUCTION VIA THE SYNOVIAL-FLUID IN RHEUMATOID-ARTHRITIS - REPLY
    LARBRE, JP
    MOORE, A
    WILLOUGHBY, DA
    JOURNAL OF RHEUMATOLOGY, 1995, 22 (07) : 1438 - 1438
  • [35] STIMULATION OF MURINE MACROPHAGE CATHEPSIN-B BY SERUM FROM PATIENTS WITH RHEUMATOID-ARTHRITIS - AN INDICATOR OF DISEASE-ACTIVITY
    OSTENSEN, M
    MORLAND, B
    HUSBY, G
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1983, 51 (01): : 103 - 109
  • [36] STIMULATION OF MACROPHAGE CATHEPSIN-B ACTIVITY BY SERUM FROM PATIENTS WITH RHEUMATOID-ARTHRITIS - AN INDICATOR OF DISEASE-ACTIVITY
    OSTENSEN, M
    HUSBY, G
    MORLAND, B
    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1982, : 23 - 23
  • [37] Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis
    Hashimoto, Y
    Kakegawa, H
    Narita, Y
    Hachiya, Y
    Hayakawa, T
    Kos, J
    Turk, V
    Katunuma, N
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 283 (02) : 334 - 339
  • [38] MLC REACTIONS BETWEEN ELUTED SYNOVIAL-CELLS AND PERIPHERAL-BLOOD LYMPHOCYTES FROM PATIENTS WITH RHEUMATOID-ARTHRITIS
    DOBLOUG, JH
    FORRE, O
    EGELAND, T
    PAHLE, JA
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1980, 12 (06) : 533 - 534
  • [39] IL-1RA-IL-1 BALANCE IN RHEUMATOID-ARTHRITIS (RA) AND OSTEOARTHRITIS (OA) SYNOVIAL-CELLS
    FIRESTEIN, GS
    PAINE, MM
    BOYLE, DL
    ZVAIFLER, CYNJ
    AREND, WP
    ARTHRITIS AND RHEUMATISM, 1992, 35 (09): : S143 - S143
  • [40] INTERLEUKIN-1 RECEPTOR ANTAGONIST PRODUCTION IN CULTURED SYNOVIAL-CELLS FROM PATIENTS WITH RHEUMATOID-ARTHRITIS AND OSTEOARTHRITIS
    FUJIKAWA, Y
    SHINGU, M
    TORISU, T
    MASUMI, S
    ANNALS OF THE RHEUMATIC DISEASES, 1995, 54 (04) : 318 - 320
12345