SYNTHETIC INHIBITORS OF INTERLEUKIN-6 .1. 2,3,7,8-TETRAHYDRO-4-ARYL-1H-CYCLOPENT[E]IMIDAZO[1,2-A]-PYRIDIN-5(6H)-ONE AND RELATED-COMPOUNDS

被引：3

作者：

TAGAT, JR ^{[1
]}

NAZARENO, DV ^{[1
]}

MCCOMBIE, SW ^{[1
]}

BARTON, BE ^{[1
]}

SHORTALL, J ^{[1
]}

JACKSON, J ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,RES INST,DEPT IMMUNOL,KENILWORTH,NJ 07033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 18期

关键词：

D O I：

10.1016/0960-894X(95)00362-W

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A versatile synthetic route to the title class of compounds and the development of an orally absorbed analogue of the lead structure are described. The minimum structural requirements needed in the compounds related to 1 for the inhibition of interleukin-6 were identified.

引用

页码：2139 / 2142

页数：4

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