AN EFFICIENT METHOD FOR ANCHORING FMOC-AMINO ACIDS TO HYDROXYL-FUNCTIONALIZED SOLID SUPPORTS

被引：179
|
作者：
BLANKEMEYERMENGE, B
NIMTZ, M
FRANK, R
机构：
[1] GBF (Gesellschaft für Biotechnologische Forschung mbH), D-3300 Braunschweig
来源：
TETRAHEDRON LETTERS | 1990年 / 31卷 / 12期
关键词：
D O I：
10.1016/S0040-4039(00)88858-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Esterification of Nα-Fmoc protected amino acid derivatives with hydroxyl-functions provided by polystyrene and cellulose derived support materials is achieved in high yields with 2,4,6-masitylenesulfonyl-3-nitro-1,2,4-triazelide (MSNT) in the presence of 1-methyltmidazole (MeIm). This reaction works reliably well with all amino acid derivatives and proceeds almost free of racemisation and dipeptide formation (1,2). © 1990.
引用
收藏
页码：1701 / 1704
页数：4
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