Tryptophanyl-tRNA synthetase as a human autoantigen

被引：16

作者：

Paley, EL

Alexandrova, N

Smelansky, L

机构：

[1] VA ENGELHARDT MOLEC BIOL INST, MOSCOW 117984, RUSSIA

[2] ONCOL SCI CTR, TASHKENT 700095, UZBEKISTAN

来源：

IMMUNOLOGY LETTERS | 1995年 / 48卷 / 03期

关键词：

autoantibodies; tryptophanyl-tRNA synthetase; interferon induction;

D O I：

10.1016/0165-2478(95)02469-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoantibodies to highly purified tryptophanyl-tRNA synthetase, consisting of two approximate to 60-kDa subunits (6.1.1.2, TrpRS), were detected in some sera of donors and patients with various diagnosis using the newly developed I-125-TrpRS-radiodot, I-125-TrpRS-radioblot, ELISA and Western immunoblotting. The percentage of positive sera appears to be dependent upon the method of sera testing. The autoimmune sera recognized both the native and denatured TrpRS forms. The binding of the human serum to the 60-kDa band of tissue extract was demonstrable by the I-125-TrpRS-blot as well as Western blot techniques. The possible role of infections in the induction of anti-TrpRS antibodies and maintenance of the autoimmune response is discussed.

引用

页码：201 / 207

页数：7

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