A LOW-THRESHOLD SUSTAINED INWARD CURRENT ACTIVATED AT THE DIASTOLIC POTENTIAL RANGE IN RABBIT SINOATRIAL NODE CELLS

被引：0
|
作者：
GUO, JQ [1 ]
ONO, K [1 ]
NOMA, A [1 ]
机构：
[1] NANJING COLL TRAD CHINESE MED,DEPT PHYSIOL,NANJING 210029,PEOPLES R CHINA
来源：
HEART AND VESSELS | 1995年
关键词：
PACEMAKER CURRENT; SINOATRIAL NODE; DIASTOLIC DEPOLARIZATION; CA2+ CHANNEL;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The whole-cell voltage clamp was performed in myocytes dissociated from the rabbit sinoatrial node using the collagenase method. After blocking both the hyperpolarization-activated current and the membrane K+ conductance, depolarizations from -80 mV to values in the range -70 to -50 mV induced a sustained current. This low-threshold sustained inward current was blocked by both organic and inorganic Ca2+ channel blockers, but tetrodotoxin 30 mu M was ineffective. Isoprenaline increased this current. It is suggested that this current plays an important role in driving the diastolic depolarization.
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页码：200 / 202
页数：3
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