THE EFFECT OF BURN WOUND SURGERY AND TEICOPLANIN ON THE BACTERICIDAL ACTIVITY OF POLYMORPHONUCLEAR LEUKOCYTES AGAINST STAPHYLOCOCCUS-AUREUS

被引：6
|
作者：
STEER, JA
HILL, GB
WILSON, APR
机构：
[1] Department of Clinical Microbiology, University College Hospital, London, WC1E 6AU, Grafton Way
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 36卷 / 05期
关键词：
D O I：
10.1093/jac/36.5.851
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Polymorphonuclear leucocyte (PMN) function is suppressed for several weeks after burn injury, rendering patients susceptible to infection, commonly with Staphylococcus aureus. A study was performed to determine the effects of surgery to the burn wound and antimicrobial prophylaxis with teicoplanin on killing of S. aureus by PMNs taken from burn patients. The bactericidal rate was significantly reduced before surgery compared to controls (P<0.01 Mann Whitney), but neither surgery nor teicoplanin had any significant additional effect on the bactericidal rate. The bactericidal rate of PMNs did not have any significant effect on clinical outcome following surgery.
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页码：851 / 855
页数：5
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