Cholecystokinin excites neostriatal neurons in rats via CCKA or CCKB receptors

被引:12
|
作者
Davidowa, H
Albrecht, D
Gabriel, HJ
Heublein, S
机构
[1] Institut für Physiologie, Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin, Berlin, D-10117
关键词
single-unit activity; CCK receptor antagonists; CCK-glutamate interaction; iontophoresis; in vivo recording;
D O I
10.1111/j.1460-9568.1995.tb01033.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of iontophoretically applied cholecystokinin (CCK) on neurons of the neostriatum was studied in rats anaesthetized with urethane. The most frequently observed effect of the sulphated octapeptide (CCK-8S) on striatal neurons was excitation. Spontaneously active neurons responded more often to CCK-8S than quiescent cells. Silent, primarily non-responsive neurons could often be stimulated with CCK-8S using glutamate to induce an ongoing discharge. Thus, 45.8% of the 177 neurons studied changed their discharge rate by more than 30%, Certain CCK receptor antagonists could prevent the effect of CCK-8S, fully or at least partly, in the majority of CCK-responsive neurons. The data suggest that cholecystokinin modulates the firing of active neostriatal neurons via the CCKA or the CCKB receptor type. Furthermore, we compared neuronal responses to glutamate with those recorded during concomitant administration of CCK-8S in order to study the interaction of both transmitters, which may be colocalized in striatal afferents, CCK-8S mainly enhanced the excitatory effect of glutamate on striatal neurons, but in several neurons the response to glutamate was reduced. The CCKB receptor antagonist could prevent CCK-8S from increasing the glutamate-induced activation.
引用
收藏
页码:2364 / 2369
页数:6
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