CLONING AND SEQUENCING OF A HUMAN THIOREDOXIN REDUCTASE

被引：174
|
作者：
GASDASKA, PY [1 ]
GASDASKA, JR [1 ]
COCHRAN, S [1 ]
POWIS, G [1 ]
机构：
[1] ARIZONA CANC CTR, TUCSON, AZ 85724 USA
来源：
FEBS LETTERS | 1995年 / 373卷 / 01期
关键词：
THIOREDOXIN REDUCTASE; HUMAN PLACENTA;
D O I：
10.1016/0014-5793(95)01003-W
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The DIVA sequence encoding human placental thioredoxin reductase has been determined. Of the 3826 base pairs sequenced, 1650 base pairs were in an open reading frame encoding a mature protein with 495 amino acids and a calculated molecular mass of 54,171. Sequence analysis showed strong similarity to glutathione reductases and other NADPH-dependent reductases. Human thioredoxin reductase contains the redox-active cysteines in the putative FAD binding domain and has a dimer interface domain not previously seen with prokaryote and lower eukaryote thioredoxin reductases.
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收藏
页码：5 / 9
页数：5
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