CLONING AND SEQUENCING OF A HUMAN THIOREDOXIN REDUCTASE

被引：174

作者：

GASDASKA, PY ^{[1
]}

GASDASKA, JR ^{[1
]}

COCHRAN, S ^{[1
]}

POWIS, G ^{[1
]}

机构：

[1] ARIZONA CANC CTR, TUCSON, AZ 85724 USA

来源：

FEBS LETTERS | 1995年 / 373卷 / 01期

关键词：

THIOREDOXIN REDUCTASE; HUMAN PLACENTA;

D O I：

10.1016/0014-5793(95)01003-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DIVA sequence encoding human placental thioredoxin reductase has been determined. Of the 3826 base pairs sequenced, 1650 base pairs were in an open reading frame encoding a mature protein with 495 amino acids and a calculated molecular mass of 54,171. Sequence analysis showed strong similarity to glutathione reductases and other NADPH-dependent reductases. Human thioredoxin reductase contains the redox-active cysteines in the putative FAD binding domain and has a dimer interface domain not previously seen with prokaryote and lower eukaryote thioredoxin reductases.

引用

页码：5 / 9

页数：5

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