FACTOR-IX BOXTEL (FACTOR-IX ARG -] TRP) - DEFECTIVE PROPEPTIDE CLEAVAGE LEADS TO DESTABILIZED CALCIUM-DEPENDENT CONFORMATION AND BLOCKS ACTIVATION BY XLA

被引：0

作者：

WOJCIK, EGC ^{[1
]}

VANDENBERQ, M ^{[1
]}

VANDERLINDEN, IK ^{[1
]}

STEEGENGA, WT ^{[1
]}

BERTINA, RM ^{[1
]}

机构：

[1] LEIDEN UNIV HOSP, HEMOSTASIS & THROMBOSIS RES CTR, DEPT HEMATOL, 2333 AA LEIDEN, NETHERLANDS

来源：

THROMBOSIS AND HAEMOSTASIS | 1993年 / 69卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：615 / 615

页数：1

共 37 条

[31] ANTIBODY PROBED CONFORMATIONAL TRANSITIONS IN THE CATALYTIC DOMAIN OF HUMAN FACTOR-IX UPON CALCIUM-BINDING AND ZYMOGEN ACTIVATION
BAJAJ, SP
MAKI, SL
BIRKTOFT, JJ
ARTERIOSCLEROSIS, 1990, 10 (05): : A894 - A895
[32] LOCALIZATION OF THE FACTOR-IX PROPEPTIDE BINDING-SITE ON RECOMBINANT VITAMIN-K-DEPENDENT CARBOXYLASE USING BENZOYLPHENYLALANINE PHOTOAFFINITY PEPTIDE INACTIVATORS
YAMADA, M
KULIOPULOS, A
NELSON, NP
ROTH, DA
FURIE, B
FURIE, BC
WALSH, CT
BIOCHEMISTRY, 1995, 34 (02) : 481 - 489
[33] THE PROPEPTIDE REGION OF CLOTTING FACTOR-IX IS A SIGNAL FOR A VITAMIN-K DEPENDENT CARBOXYLASE - EVIDENCE FROM PROTEIN ENGINEERING OF AMINO-ACID -4
GALEFFI, P
BROWNLEE, GG
NUCLEIC ACIDS RESEARCH, 1987, 15 (22) : 9505 - 9513
[34] MOLECULAR DEFECTS OF FACTOR-IX CHICAGO-2 (ARG 145-]HIS) AND PROTHROMBIN MADRID (ARG 271-]CYS) - ARGININE MUTATIONS THAT PRECLUDE ZYMOGEN ACTIVATION
DIUGUID, DL
RABIET, MJ
FURIE, BC
FURIE, B
BLOOD, 1989, 74 (01) : 193 - 200
[35] INVITRO GAMMA-CARBOXYLATION OF A 59-RESIDUE RECOMBINANT PEPTIDE INCLUDING THE PROPEPTIDE AND THE GAMMA-CARBOXYGLUTAMIC ACID DOMAIN OF COAGULATION FACTOR-IX - EFFECT OF MUTATIONS NEAR THE PROPEPTIDE CLEAVAGE SITE
WU, SM
SOUTE, BAM
VERMEER, C
STAFFORD, DW
JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (22) : 13124 - 13129
[36] MOLECULAR DEFECT IN FACTOR-IX TOKYO - SUBSTITUTION OF VALINE-182 BY ALANINE AT POSITION P2' IN THE 2ND CLEAVAGE SITE BY FACTOR-XIA RESULTING IN IMPAIRED ACTIVATION
MAEKAWA, H
SUGO, T
YAMASHITA, N
KAMIYA, K
UMEYAMA, H
MIURA, N
NAKA, H
NISHIMURA, T
YOSHIOKA, A
MATSUDA, M
BIOCHEMISTRY, 1993, 32 (24) : 6146 - 6151
[37] ANTIBODY-PROBED CONFORMATIONAL TRANSITIONS IN THE PROTEASE DOMAIN OF HUMAN FACTOR-IX UPON CALCIUM-BINDING AND ZYMOGEN ACTIVATION - PUTATIVE HIGH-AFFINITY CA2+-BINDING SITE IN THE PROTEASE DOMAIN
BAJAJ, SP
SABHARWAL, AK
GORKA, J
BIRKTOFT, JJ
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) : 152 - 156

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