Ketorolac tromethamine 0.4% to relieve eye pain and inflammation following cataract extraction and keratorefractive surgery

Ketorolac tromethamine ophthalmic solution, a NSAID, demonstrated analgesic activity when administered systemically. The original 0.5% formulation was shown to reduce inflammation and pain, as well as general discomfort after cataract and keratorefractive surgery. A reformulation that contains 20% less active ingredient than the original was approved for the reduction of ocular pain and burning/stinging following corneal refractive surgery. Ketorolac tromethamine 0.4% is as effective as ketorolac tromethamine 0.5% to control inflammation after cataract surgery (including prevention of cystoid macular edema) as shown in different clinical trials. Comparisons to other NSAIDs for pain control after keratorefractive procedures, such as laser-assisted in situ keratomileusis and photorefractive keratectomy, have also been reported. The purpose of this study was to review the action of ketorolac tromethamine 0.4% in the relief of eye pain and inflammation after cataract extraction and keratorefractive surgery.