The isomerization chlorination of O,O-dialkyl methylthiophosphonates with phosphorus oxychloride - A new convenient synthesis of S-alkyl methylthiophosphonic acid derivatives

被引：12
|
作者：
Tang, CC
Ma, FP
Zhang, K
He, ZJ
Jin, YC
机构：
[1] Institute of Elemento-Organic Chemistry, Nankai University, Tianjin
来源：
HETEROATOM CHEMISTRY | 1995年 / 6卷 / 05期
关键词：
D O I：
10.1002/hc.520060506
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new method for the synthesis of S-alkyl methylthiophosphonic acid derivatives is reported. The chlorination of O,O-dialkyl methylthiophosphonates 8 with phosphorus oxychloride proceeds with isomerization of the P = S to the P-S bond to give S-alkyl methylthiophosphonochloridates 9, which react further with various nucleophiles in the presence of triethylamine to afford S-alkyl methylthiophosphonic acid derivatives 10. Among them, several compounds 10 show excellent fungicidal or insecticidal activities. (C) 1995 John Wiley & Sons, Inc.
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页码：413 / 417
页数：5
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