INCREASED URINARY-EXCRETION OF PYRIDINIUM CROSS-LINKS IN CANCER-PATIENTS

被引：0
|
作者：
LIPTON, A
DEMERS, L
DANILOFF, Y
CURLEY, E
HAMILTON, C
HARVEY, H
WITTERS, L
SEAMAN, J
VANDERGIESSEN, R
SEYEDIN, S
机构：
[1] METRA BIOSYST INC,PALO ALTO,CA
[2] CIBA GEIGY CORP,SUMMIT,NJ 07901
[3] CIBA GEIGY AG,CH-4002 BASEL,SWITZERLAND
来源：
CLINICAL CHEMISTRY | 1993年 / 39卷 / 04期
关键词：
PYRIDINOLINE; DEOXYPYRIDINOLINE; BONE METASTASES; COLLAGEN CROSS-LINKS; CHROMATOGRAPHY; LIQUID; FLUOROMETRY;
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Pyridinoline (PYD) and deoxypyridinoline (DPD), two collagen-based cross-links found in bone, were measured by high-performance liquid chromatography in urine samples from 65 control subjects and 97 patients with either untreated or progressive cancer. Patients with cancer had significantly (P <0.001) higher urine concentrations of PYD and DPD than did control subjects. Both cross-links were increased in cancer patients with and without clinically detectable bone metastases, although patients with bone and liver involvement had higher mean concentrations. The mean concentrations of both cross-links were also significantly higher in the urine samples of inpatients than in an outpatient ambulatory population. These findings suggest that the measurement of PYD and DPD in urine may be useful in assessing bone metastases and bone resorption in cancer patients.
引用
收藏
页码：614 / 618
页数：5
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