Neurotransmitter Systems of Some Brain Regions of Rats Subjected to Chronic Morphine Intoxication

被引：0
|
作者：
Lelevich, S. V. [1 ]
Novokshonov, A. A. [2 ]
机构：
[1] Grodno State Med Univ, Ul Gorkogo 80, Grodno 230009, BELARUS
[2] Natl Acad Sci, Inst Biochem, Grodno 230017, BELARUS
来源：
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY | 2011年 / 5卷 / 02期
关键词：
morphine; brain; dopamine; noradrenaline; serotonin; GABA;
D O I：
10.1134/S1990750811020065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The content of neurotransmitters and their metabolites was investigated in brain cortex hemispheres, thalamus and brainstem of rats subjected to chronic morphine intoxication (7-21 days). Morphine administration for 7-14 days was accompanied by changes of the catecholamine system functioning, which was the most pronounced in the thalamus and the brainstem. These changes included increased secretion of dopamine and noradrenaline, their decrease in the brain tissue, and an increased content of their metabolites. The changes in serotonin and GABA content were less pronounced and included a decrease of serotonin level and the increase of the GABA content in different periods of opiate administration.
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页码：175 / 179
页数：5
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