FLOW CYTOMETRIC AND MOLECULAR ANALYSIS OF PROLIFERATIVE ACTIVITY AND DNA CONTENT IN NEUROBLASTOMA - PRESENCE OF STATIONARY CELLS IN S-PHASE

被引：0

作者：

DOMINICI, C

NEGRONI, A

ROMEO, A

MCDOWELL, H

PADULA, A

PUCCI, S

CAPPELLI, C

CASTELLO, MA

RASCHELLA, G

机构：

[1] INST GUSTAVE ROUSSY,CLIN & MOLEC PHARMACOL LAB,F-94805 VILLEJUIF,FRANCE

[2] ENTE NATL ENERGIA ATOM CASACCIA,CTR RIC ENERGIA,DIV MOLEC BIOL,I-00060 ROME,ITALY

来源：

ANTICANCER RESEARCH | 1992年 / 12卷 / 01期

关键词：

NEUROBLASTOMA; CYTOKINETICS; DNA CONTENT; N-MYC; HISTONE-H3;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty-nine previously untreated neuroblastomas were analyzed for DNA content and percentage of cells in S-phase, both determined by flow cytometry, and N-myc oncogene copy number. Twelve of them were also tested for histone H3 transcript levels as a marker of actual proliferative activity. A significantly higher S-phase fraction was associated with advanced stages of disease, unfavorable (i.e., near-diploid and near-tetraploid) DNA content, and N-myc amplification. The occurrence of six tumors with a remarkable (greater-than-or-equal-to 10%) S-phase fraction but lacking histone H3 transcripts suggests the presence of stationary S-phase cells in neuroblastoma.

引用

页码：59 / 63

页数：5

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