IMMUNOCYTOCHEMICAL ANALYSIS OF RECEPTORS FOR ESTROGEN AND PROGESTERONE IN FINE-NEEDLE ASPIRATES FROM HUMAN BREAST CARCINOMAS

被引：36
|
作者：
SKOOG, L
HUMLA, S
ISAKSSON, S
TANI, E
机构：
[1] Division of Clinical Cytology, Department of Pathology, Karolinska Hospital, Stockholm
来源：
DIAGNOSTIC CYTOPATHOLOGY | 1990年 / 6卷 / 02期
关键词：
Breast carcinoma; Fine‐needle aspiratio; Immunocytochemistry; Progesterone and estrogen receptors;
D O I：
10.1002/dc.2840060205
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Monoclonal antibodies were used for a preoperative analysis of estrogen receptors (ERs) and progesterone receptors (PgRs) in fine‐needle aspirates from 44 primary human breast carcinomas. The semiquantitative receptor values obtained in cytologic specimens correlated well with those from enzyme immunoassay analysis on surgically removed tumor tissue (r = 0.74 for PgR;r = 0.75 for ER). Cytologic smears showed a heterogenous tumor cell distribution of ER and PgR in 29 and 23 cases, respectively. The results suggest that measurement of the ER and PgR in cytologic smears is an accurate and reliable technique that can be performed on a minimum amount of tissue. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：95 / 98
页数：4
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