ERYTHROCYTE THIOLMETHYLTRANSFERASE - ANOTHER FAILED MARKER FOR ALZHEIMERS AND PARKINSONS DISEASES

被引：4

作者：

HURWITZ, A ^{[1
]}

HUBBLE, JP ^{[1
]}

GLATT, SL ^{[1
]}

KOLLER, WC ^{[1
]}

POLLACK, J ^{[1
]}

机构：

[1] UNIV KANSAS,MED CTR,DEPT NEUROL,KANSAS CITY,KS 66160

来源：

NEUROLOGY | 1995年 / 45卷 / 10期

关键词：

D O I：

10.1212/WNL.45.10.1903

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There are reports that patients with Parkinson's disease (PD) and Alzheimer's disease (AD) have reduced levels of thiolmethyltransferase (TMT) in erythrocyte membranes. TMT methylates thiols and thiocarbamates, thereby reducing their toxicity. We examined TMT levels in erythrocytes from patients with PD and AD and from age-matched controls. Specific activities of TMT were 564 +/- 199 U/mg protein in PD (n = 32), 513 +/- 118 in AD (n = 13), and 565 +/- 183 in controls (n = 35). There was no difference between any of the groups (p = 0.64). We failed to confirm TMT as a marker for neurodegenerative diseases or for this metabolic defect predisposing to susceptibility to neurotoxins.

引用

页码：1903 / 1906

页数：4

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