THE ORTHO EFFECT IN PYRIDINES .12. SUBSTITUENT EFFECTS ON BASICITY OF 3-SUBSTITUTED 2-AMINOPYRIDINES AND 4-AMINOPYRIDINES

被引：0
|
作者：
RASALA, D
机构：
来源：
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE | 1992年 / 129卷 / 05期
关键词：
SUBSTITUENT EFFECTS; 3-SUBSTITUTED 2-AMINOPYRIDINES AND 4-AMINOPYRIDINES; BASICITY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The basicities of 25 3-substituted 2- and 4-aminopyridines were investigated. The results are compared with each other and with data from two previously-studied series. In general, the overall substituent effect is sensitive to the distance of both the R and the NH2 groups from the ring nitrogen atom. The field/inductive-resonance composition of the interaction between the substituent and the reaction site depends on the possibility of conjugation of the exocyclic groups with the pyridine ring. The influence of tautomeric equilibria and the hydration effect are discussed.
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页码：509 / 512
页数：4
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