DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS BY HEXAMETHYLENEBISACETAMIDE INVOLVES SECRETION AND BINDING TO MEMBRANES OF A DIFFERENTIATION ENHANCING FACTOR

被引：8
|
作者：
SPARATORE, B
PATRONE, M
PASSALACQUA, M
MELLONI, E
PONTREMOLI, S
机构：
[1] Institute of Biological Chemistry University of Genoa, 16132 Genoa
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 01期
关键词：
D O I：
10.1016/0006-291X(91)91348-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A protein factor previously shown to enhance terminal differentiation of transformed erythroid cells is synthesized by murine erythroleukemia cells and secreted in the early stages of differentiation induced by hexamethylenebisacetamide (HMBA). Secretion also occurs, constitutively, in the absence of inducer, from a murine erythroleukemia cell variant characterized by an accelerated response to HMBA. The protein factor binds to intact cells following addition of HMBA and enhances translocation of protein kinase C to the nuclear fraction. These results strongly support an important role for this natural protein factor in cell differentiation. © 1991.
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页码：153 / 160
页数：8
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