DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS BY HEXAMETHYLENEBISACETAMIDE INVOLVES SECRETION AND BINDING TO MEMBRANES OF A DIFFERENTIATION ENHANCING FACTOR

被引：8
|
作者：
SPARATORE, B
PATRONE, M
PASSALACQUA, M
MELLONI, E
PONTREMOLI, S
机构：
[1] Institute of Biological Chemistry University of Genoa, 16132 Genoa
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 01期
关键词：
D O I：
10.1016/0006-291X(91)91348-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A protein factor previously shown to enhance terminal differentiation of transformed erythroid cells is synthesized by murine erythroleukemia cells and secreted in the early stages of differentiation induced by hexamethylenebisacetamide (HMBA). Secretion also occurs, constitutively, in the absence of inducer, from a murine erythroleukemia cell variant characterized by an accelerated response to HMBA. The protein factor binds to intact cells following addition of HMBA and enhances translocation of protein kinase C to the nuclear fraction. These results strongly support an important role for this natural protein factor in cell differentiation. © 1991.
引用
收藏
页码：153 / 160
页数：8
相关论文
共 50 条
  • [1] QUEUINE IN DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS
    KERR, SJ
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1985, 26 (MAR): : 36 - 36
  • [2] DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS BY HEXAMETHYLENEBISAMIDE ANALOGS
    MATSUO, T
    IMAMURA, T
    FUJITA, K
    YANASE, T
    ACTA HAEMATOLOGICA JAPONICA, 1984, 47 (04): : 926 - 937
  • [3] EFFECTS OF TRICHOSTATINS ON DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS
    YOSHIDA, M
    NOMURA, S
    BEPPU, T
    CANCER RESEARCH, 1987, 47 (14) : 3688 - 3691
  • [4] CHARACTERIZATION OF THE BIOLOGICAL ROLE OF MURINE ERYTHROLEUKEMIA-CELLS DIFFERENTIATION ENHANCING FACTOR USING ANTISENSE OLIGODEOXYNUCLEOTIDES
    SPARATORE, B
    PATRONE, M
    PASSALACQUA, M
    PESSINO, A
    FALCHETTO, R
    MELLONI, E
    PONTREMOLI, S
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 193 (03) : 941 - 947
  • [5] DIFFERENTIATION OF HL-60 PROMYELOCYTIC CELLS IS PROMOTED BY A DIFFERENTIATION ENHANCING FACTOR PRODUCED BY ERYTHROLEUKEMIA-CELLS
    SPARATORE, B
    PASSALACQUA, M
    PATRONE, M
    PESSINO, A
    MELLONI, E
    PONTREMOLI, S
    FEBS LETTERS, 1993, 334 (02) : 198 - 202
  • [6] DIFFERENTIATION INDUCTION OF MURINE ERYTHROLEUKEMIA-CELLS BY BUTYLATED HYDROXYTOLUENE
    OHNO, Y
    TAKUMA, T
    ASAHI, K
    ISONO, K
    FEBS LETTERS, 1984, 165 (02) : 277 - 279
  • [7] RIBAVIRIN INDUCED-DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS
    KERR, SJ
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1987, 77 (02) : 187 - 194
  • [8] SULFHYDRYL-GROUPS AND THE DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS
    MARESCA, B
    JAFFE, BM
    SANTORO, MG
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 91 (03) : 1148 - 1156
  • [9] INHIBITION OF FERROCHELATASE DURING DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS
    FADIGAN, A
    DAILEY, HA
    BIOCHEMICAL JOURNAL, 1987, 243 (02) : 419 - 424
  • [10] METHYLATED OXYPURINES AND INDUCTION OF DIFFERENTIATION OF MURINE ERYTHROLEUKEMIA-CELLS
    KERR, SJ
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1990, 92 (01) : 37 - 44
12345