HB FUKUTOMI [ALPHA-126(H9)ASP-]VAL] - A NEW HEMOGLOBIN-VARIANT WITH HIGH OXYGEN-AFFINITY

被引：7
|
作者：
HIDAKA, K [1 ]
IUCHI, I [1 ]
KOBAYASHI, T [1 ]
KATOH, K [1 ]
YAGUCHI, K [1 ]
机构：
[1] KAWASAKI HOSP, KAWASAKI MED SCH,DEPT INTERNAL MED, OKAYAMA 700, JAPAN
来源：
HEMOGLOBIN | 1990年 / 14卷 / 05期
关键词：
D O I：
10.3109/03630269009005803
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hb Fukutomi [alpha-126(H9)Asp-->Val], a new hemoglobin variant with a high affinity for oxygen (log P50 = 0.201 at pH 7.0, normal = 1.087) was detected in a Japanese male during a screening survey. The amino acid substitution is located in the alpha1beta1 contact of the tetramic molecule. Like other variants of the high oxygen affinity type Hb Fukutomi showed increased resistance to auto-oxidation. The tryptic peptide alpha-T-13, that usually forms part of the trypsin-resistant core of the alpha chain, was cleaved off by trypsin in the new variant and released into the soluble fraction.
引用
收藏
页码：499 / 509
页数：11
相关论文
共 50 条
  • [1] HETEROZYGOSITY AND HOMOZYGOSITY FOR THE HIGH OXYGEN-AFFINITY HEMOGLOBIN TARRANT OR ALPHA-126 (H9) ASP-]ASN IN 2 MEXICAN FAMILIES
    IBARRA, B
    VACA, G
    CANTU, JM
    WILSON, JB
    LAM, H
    STALLINGS, M
    GRAVELY, ME
    HUISMAN, THJ
    HEMOGLOBIN, 1981, 5 (04) : 337 - 348
  • [2] HEMOGLOBIN TARRANT - ALPHA-126(H9) ASP-]ASN - NEW HEMOGLOBIN VARIANT IN ALPHA-1BETA-1 CONTACT REGION SHOWING HIGH OXYGEN-AFFINITY AND REDUCED COOPERATIVITY
    MOOPENN, WF
    JUE, DL
    JOHNSON, MH
    WILSON, SM
    THERRELL, B
    SCHMIDT, RM
    BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 490 (02) : 443 - 451
  • [3] A new Hb variant altering an important contact area: Hb west one (alpha 126(H9)Asp->Gly)
    Wajcman, H
    Kister, J
    Griffon, N
    Prome, D
    Davies, SC
    Galacteros, F
    Henthorn, JS
    BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 : 107 - 107
  • [4] HEMOGLOBIN BARCELONA-BETA 94 (FG1) ASP-] HIS - A NEW HEMOGLOBIN-VARIANT WITH INCREASED OXYGEN-AFFINITY
    BASCOMPTE, JLIAI
    WAJCMAN, H
    POYART, C
    LABIE, D
    NOUVELLE REVUE FRANCAISE D HEMATOLOGIE, 1981, 23 (05): : 267 - 273
  • [5] Hb Montefiore (alpha 126(H9)Asp->Tyr) - High oxygen affinity and loss of cooperativity secondary to C-terminal disruption
    Wajcman, H
    Kister, J
    Galacteros, F
    Spielvogel, A
    Lin, MJ
    Vidugiris, GJA
    Hirsch, RE
    Friedman, JM
    Nagel, RL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (38) : 22990 - 22998
  • [6] HEMOGLOBIN CONNECTICUT (BETA-21(B3) ASP-]GLY) - A HEMOGLOBIN-VARIANT WITH LOW OXYGEN-AFFINITY
    MOOPENN, WF
    MCPHEDRAN, P
    BOBROW, S
    JOHNSON, MH
    JUE, DL
    OLSEN, KW
    AMERICAN JOURNAL OF HEMATOLOGY, 1981, 11 (02) : 137 - 145
  • [7] HB VAL-DE-MARNE [ALPHA-133(H16)SER-]ARG] - A NEW HEMOGLOBIN-VARIANT WITH MODERATE INCREASE IN OXYGEN-AFFINITY
    WAJCMAN, H
    KISTER, J
    MRAD, A
    MARDEN, MC
    RIOU, J
    GALACTEROS, F
    HEMOGLOBIN, 1993, 17 (05) : 407 - 417
  • [8] HB POITIERS [ALPHA-45(CE3)HIS-]ASP] - A NEW HEMOGLOBIN-VARIANT WITH A 2-FOLD INCREASE IN OXYGEN-AFFINITY
    BARDAKDJIAN, J
    KISTER, J
    WAJCMAN, H
    BOULARD, P
    BOHN, B
    BLOUQUIT, Y
    GALACTEROS, F
    HEMOGLOBIN, 1994, 18 (01) : 1 - 9
  • [9] A NEW UNSTABLE AND LOW OXYGEN-AFFINITY HEMOGLOBIN-VARIANT - HB STANMORE [BETA-111(G13)VAL-]ALA]
    COMO, PF
    WYLIE, BR
    TRENT, RJ
    BRUCE, D
    VOLPATO, F
    WILKINSON, T
    KRONENBERG, H
    HOLLAND, RAB
    TIBBEN, EA
    HEMOGLOBIN, 1991, 15 (1-2) : 53 - 65
  • [10] HB-TIGRAYE OR ALPHA(2)BETA(2)79(EF3)ASP-]HIS(GAC-]CAC) - A HEMOGLOBIN-VARIANT WITH INCREASED OXYGEN-AFFINITY OBSERVED IN AN ETHIOPIAN MALE
    MOLCHANOVA, TP
    POSTNIKOV, YV
    GU, LH
    PRIOR, JF
    RAVEN, JL
    BENNETT, JA
    HUISMAN, THJ
    HEMOGLOBIN, 1993, 17 (03) : 247 - 250
12345